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GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

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A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations

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10.1111/j.1464-5491.2012.03587.x 234 WirthM.BensonG.SchwarzC.KbeT.GrittnerU.SchmitzD.et al (2018)

In particular, variations in the transcripts for the ThDP-dependent enzymes with relatively high enterocytic expression, i.e., OGDH, HACL1 and PDHA1, are coupled with those in the transcripts for ALPI and ThDP transporter SLC44A4, all belonging to the cluster 2b including the three proteins with decreased transcripts 1 month after the bypass (Figure 5A in bold)