And in addition to causing your pancreas to release insulin, Semaglutide also blocks a hormone that causes your liver to release sugar (glucagon)
Its effectiveness is attributed to its unique mechanism of action, which imitates the functions of the endogenous GLP-1 hormone , an incretin hormone that plays an instrumental role in regulating glucose metabolism
This is higher than other GLP-1s, which had discontinuation rates of 6.1% (tirzepatide), 8.0% (semaglutide) and 10.3% (orforglipron)
No special post-treatment care is required
The pharmaceutical industry, represented by the trade organization PhRMA, would like to see Medicare rules changed to allow more patients to take the drugs and is pushing for more oversight and reining in of some of the compounding pharmacies that sell GLP-1 drugs directly to consumers
The specific schedules differ because the maintenance doses reach different ranges