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The metabolic impact hierarchy clearly demonstrates that nutrition, exercise, sleep, and stress management produce effects orders of magnitude larger than any supplement intervention 45 Strasser, B

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Assessed 15 May 2021

doi: 10.1152/physrev.00024.2010 107 Vila PetroffMGEganJMWangXSollottSJ

Phase III clinical data from SCENESSE trials (the FDA-approved formulation of afamelanotide) demonstrated that patients with erythropoietic protoporphyria achieved clinically meaningful photoprotection after 60 days of sustained drug delivery via controlled-release implant

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