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Novel unimolecular, multifunctional peptides have emerged as one of the most promising medicinal approaches to enhance metabolic efficacy and restore normal body weight

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10.3389/fphar.2021.781640 53 LiangY.LiuZ.-Y.WangP.-Y.LiY.-J.WangR.-R.XieS.-Y

ABSTRACT KEY FIGURE Highlights The DEVELOPMENT AND USE OF GLUCAGON-LIKE PEPTIDE-1 STRUCTURE, DISTRIBUTION, AND PHYSIOLOGICAL FUNCTION OF GLP-1 GLP-1 MODULATES LIPID METABOLISM CLINICAL APPLICATION OF GLP-1 IN LIPID METABOLISM AND ADIPOSE-RELATED DISORDERS GLP-1 AND DUAL AGONISTS CONCLUSIONS NOTES REFERENCES About this article ABSTRACT Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus

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