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As GLP-1 receptor agonists gain wider use for metabolic disease and weight management, dermatologists, primary care clinicians, researchers, and patients are seeking clear information about possible cutaneous effects, rare adverse events, and potential therapeutic interactions

GLP-1 modulates appetite through two primary mechanisms: First, it upregulates key gastrointestinal hormones like CCK, gastrin, and GIP, which support digestion and send satiety signals to the brain

A history of Pancreatitis

The injectable GLP-1s do have a fairly long half-life, of about four or so weeks

This matters beyond the osteoarthritis indication

5 Providers should set realistic expectations, encourage lifestyle changes and address barriers such as cost and insurance hurdles