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This region has four subdomains: F0, F1, F2 and F3

GO and KEGG enrichment analyses DAVID 6.8 ( and KOBAS 3.0 ( were used for Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses

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For those focused on early prediction and prevention, these findings reinforce a critical message: interventions must begin in preclinical stages where biological pathways remain modifiable