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This formulation is supplied in pre-standardised research delivery format to support consistent compound composition, controlled laboratory handling, and reproducibility across non-clinical experimental workflows
The combination of sterile water and benzyl alcohol adds an anti-bacterial element meaning that repeated withdrawals can be made from a single vial
By reducing gut-derived BAs entering the liver, IBAT inhibitors may potentially reduce the liver damage in cholestatic liver disease, and IBAT inhibitors, such as maralixibat and odevixibat, are in clinical programs for treating pediatric cholestatic liver diseases ( The secondary BAs LCA and DCA are hydrophobic and unconjugated, and considered to be cytotoxic, which are related to intestinal barrier damage and liver cell injury
This high purity lyophilized powder is available in 2mg, 5mg, and 10mg vials, or as complete kits supplied with bacteriostatic water and syringes for accurate reconstitution
