It is not a FDA approved as a drug and the safety profile is still not clear
These issues can be addressed by future research that standardizes intervention and measurement protocols, broadens the study population, controls all confounding variables, and strengthens the studys design
The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit
doi: 10.1111/and.v51.10 102 MajzoubAAgarwalA
Exogenous GLP-2 administration increases gut weight and is highly effective in the clinical management of short bowel syndrome (72, 73)
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