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We conclude that despite data in support of anti-aging benefits, the evidence that metformin increases lifespan remains controversial

Reddy YNV et al (2024) Dapagliflozin, peptide YY, and weight loss in heart failure with preserved ejection fraction

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Additionally, even if you dont have an MTHFR gene mutation, your toxic burden, which is an accumulation of toxins in your body, can affect the methylation process