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Rare but serious events such as pancreatitis (inflammation of the pancreas) or medullary thyroid cancer remain under surveillance because of animal toxicity signals

Chertkoff, A

Tamayo M, Martin-Nunes L, Val-Blasco A, et al

MYC-dependent enhancement of mitochondrial glutaminolysis leads to the reprogramming of mitochondrial metabolism to accommodate the requirements for TCA cycle anaplerosis to sustain cellular viability and growth

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This is due to its long history and proven effectiveness in treating type 2 diabetes