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Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes
"I don't think the companies have leveled with the American public on how these drugs work," says Kessler
But knowing the general trajectory helps set expectations and prevents premature frustration
20 After 52 weeks, steatohepatitis resolved without fibrosis progression in 44%, 56%, and 62% of participants receiving tirzepatide at doses of 5 mg, 10 mg, and 15 mg, respectively, compared to 10% in the placebo group
Pharmaceutical scientists at Eli Lilly designed tirzepatide as a synthetic molecule from the ground up, engineering a single peptide chain that could activate both GIP and GLP-1 receptors with optimized potency and duration of action
doi: 10.1210/jc.2016-2965 2 NederstigtCCorssmitEPde KoningEJDekkersOM
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