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Mahapatra, S

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Heritage and perspectives POMC and its derivatives have been discovered over nearly a century: alpha-MSH identification by Harris in the 1950s, POMC characterization by Nakanishi and Numa (Nature, 1979), cloning of the five MC1R-MC5R receptors between 1992 and 1994 (Cone, Mountjoy, Gantz teams)

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The left part was decomposed and used for western blot, and the right part was immediately placed in cold 4% PFA at 4 C for 2 days, and then dehydrated in 30% sucrose solution for 2 days, and then embedded and frozen with OCT

However, the effectiveness of traditional treatment methods for osteosarcoma is still limited, as the 5-year survival rate falls within the range of 60% to 70%