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Yes, vitamin B12 is water-soluble, so there is no concern about toxicity

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The medication is administered as a once-weekly subcutaneous injection with doses titrated from 2.5 mg up to 15 mg

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The changes in biological metabolites (e.g., iron and lipids) support ferroptosis as a potential therapeutic strategy for RCC, while iron metabolism and ferroptosis regulation have been examined as anti-RCC agents in numerous studies, and various ferroptosis-related molecules have been shown to be related to the metastasis and prognosis of ccRCC