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Any dysfunction in shelterin components can lead to telomere uncapping, exposing telomeres to degradation, recombination, and chromosomal end-to-end fusions, inducing genomic instability potentially resulting in cellular senescence (Sfeir and de Lange, 2012)

This transcription factor acts as a master regulator of lysosome biogenesis, thereby promoting autophagosome-lysosome clearance of A by astrocytes [69]

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