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Statistical analysis Statistical analyses were performed using IBM SPSS Statistics version 26.0 (IBM Corp., Armonk, NY, USA) and GraphPad Prism version 5.01 (GraphPad Software, San Diego, CA, USA)

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In endothelial cells, the ERK1/2 pathway is activated in a Ca 2+ -dependent manner 48,49 and ERK1/2 activation exacerbates renal fibrosis 50