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Kosower, N

Henderson, J

36 showed that the neurotoxic activation of microglia with LPS can be reduced in the presence of elevated UA, an effect shown to be mediated by cellular UA uptake

Strategies for managing gastrointestinal side effects: Eat smaller, more frequent meals : Rather than three large meals, consume five to six smaller portions throughout the day Avoid high-fat and spicy foods : These can exacerbate nausea and slow digestion further Stay well-hydrated : Drink water regularly throughout the day, particularly if experiencing diarrhoea or vomiting Maintain consistent timing : Administer Ozempic on the same day each week, at any time of day, with or without food Avoid lying down immediately after eating : Remain upright for at least 30-60 minutes after meals For injection site reactions: Rotate injection sites systematically (abdomen, thigh, upper arm) Use proper injection technique as demonstrated by your diabetes nurse Apply a cold compress if irritation occurs Inspect the solution before use - it should be clear and colourless General management principles: Gradual dose escalation is fundamental to tolerability

Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4

Exp Eye Res