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In the trial-product estimand, 19.3% of participants achieved a reduction of at least 30% in body weight

Whats more, they replicated the same analyses in a separate cohort of patients with type 2 diabetes mellitus by comparing semaglutide with non-GLP1R agonist anti-diabetes medications

consult your provider if persistent or severe

In animal models, semaglutide reduces food intake and body weight by activating Adcyap1-expressing neurons in the dorsal vagal complex, a key integrator of gutbrain signals that induce a reduction in food intake via both homeostatic and hedonic pathways [78]

Rodrguez-Daza MC, Pulido-Mateos EC, Lupien-Meilleur J, Guyonnet D, Desjardins Y, Roy D

W.J.H., Elders, P.J.M., Lips, P., Dhonukshe-Rutten, R.A.M., Van Schoor, N.M., and De Groot, L.C.P.G.M