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Refrigeration at 2-8C significantly slows degradation kinetics

Mapelli, C

Administration technique proves critical - head tilted slightly forward not back to prevent throat drainage, alternating nostrils with 1-2 minute intervals, avoiding immediate deep sniffing, and allowing adequate mucosal contact time

Its relevance here comes from a 2018 murine study in which intranasal Semax at 0.5 mg/kg daily decreased LPS-induced serum TNF- and IL-1 by 45 to 50% and restored tight junction protein expression (claudin-2, occludin) over a 14-day intestinal inflammation model

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As a prebiotic, its function is to selectively feed beneficial bacteria rather than directly introducing organisms