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In AD models, Nrf2 deficiency exacerbates oxidative stress, leading to increased lipid peroxidation and DNA damage, particularly in astrocytes, which accelerates neurodegeneration and inflammation

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The AFBO is highly unstable, and it reacts with cellular nucleophiles and can induce mutations by alkylating DNA, principally at the N 7 position of guanine forming the 8,9-dihydro- 8-(N 7 -guanyl)-9-hydroxy-AFB 1