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Multiple 20242026 systematic reviews and meta-analyses have compiled the early-phase data (PMID 39318607, PMID 40291085, PMID 40685589, PMID 40728138, PMID 41785010)

At present, the therapeutic application and potential value of GLP-1RAs in diseases other than diabetes has become a research hotspot

They are prepared by compounding pharmacies under a valid prescription

Weight loss is important, but clinicians may also consider A1C, blood pressure, lipids, cardiovascular risk, liver fat, tolerability, medication interactions, quality of life, and long-term maintenance

Research protocols that transition between compounds use sequential designs with adequate clearance periods

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