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Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders

doi: 10.1016/j.diabres.2021.109119 4 ShahADLangenbergCRapsomanikiEDenaxasSPujades-RodriguezMGaleCPet al

The blend contains multiple compounds with different charge states, ionization efficiencies, molecular masses and metal-association behavior

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