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Ann Rep Med Chem 2007

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This pathway comprehends glutathione-insulin transhydrogenase (GIT) action, followed by hydrolysis of intact A and B chains by lysosomal proteases, and seems to need insulin internalization

These antibodies are found in: Pernicious anemia (55-90% of cases) Chronic gastritis (up to 60%) Autoimmune thyroid disorders such as Hashimoto's or Graves' disease They indicate an immune reaction against the stomach wall, causing the stomach to produce less acid and decrease intrinsic factor

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