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247 The primary action often occurs through indirect mechanisms, such as insulin and somatostatin

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Mounjaro is tirzepatide, which activates both GLP-1 and GIP pathways

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Os autores ressaltam, porm, que os achados ainda so preliminares e dependem de novos estudos clnicos em humanos

Ojima A, Ishibashi Y, Matsui T et al (2013) Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression