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OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

All of these changes in the normal RNA chain can lead to disruption of normal gene expression or adverse changes in protein synthesis (85)

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Lombardo L 1 , Foti M, Ruggia O, Chiecchio A

However, a highly stable form of BPC-157 called BPC-157 arginate has recently been developed, exhibiting oral bioavailability of over 90%

Accidental exposure of the eyes to the vapour of ethylene oxide can lead to conjunctivitis (Thiess, 1963