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Dungan KM, Hertz CL, Mellbin L, Abildlund Nielsen M, Srrig R, Woo VC, et al

Overview of Linzess/Constella Linzess (Linaclotide) was initially approved by the U.S

The placeholder was then exchanged with a panel of five peptide P2 (IIDKSG xx V) variants that differ only at p7 and p8, which are the principal KIR binding determining residues [6, 10, 13]

Doses start at 0.25 mg weekly, increasing every 4 weeks until reaching a maintenance dose of 2.4 mg weekly, if tolerated

Drugs Targeting Traditional Metabolic Pathways GDF8-Targeting Drugs Drugs targeting GDF8 focus on either its latent or mature forms

10.1016/j.yjmcc.2018.07.250 87 LiR.WangX.WuS.WuY.ChenH.XinJ.et al (2019)