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Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that is essential for human health

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Safety and efficacy of compounded bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Here is a summary of results across the major trials

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however, it requires self-administration via syringe , increasing complexity and risk of dosing errors