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ShD14 and OsD14 have bulky residues in their pockets, such as F125 ShD14 /F176 OsD14 , W154 ShD14 /W205 OsD14 , and F194 ShD14 /F245 OsD14 (corresponding to residues 124, 153, and 194 in ShHTLs), making their pockets smaller than those of the divergent clade (Fig

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