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In rodents, SPNs in the C8-T2 segments innervate primarily the superior cervical and middle cervical-stellate ganglion complex 43,44,45,46,47,48,49 , from which postganglionic neurons innervate the heart, salivary glands and the eyes, among other targets 47,50,51,52

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The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction

Such accounts are not merely descriptive

Point estimates are represented as circles, and horizontal bars indicate 95% confidence intervals