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Extended periods of fasting may precipitate spikes and subsequent crashes in blood sugar, exacerbating the symptoms of adrenal fatigue and potentially hindering the healing process

Theoretical and Class-Level Risks These have not been confirmed in cagrilintide trials but are flagged because they appear in related amylin or GLP-1 class data: pancreatitis, gallbladder disease, severe hypoglycemia (mainly when combined with insulin or sulfonylureas), and acute kidney injury secondary to dehydration from severe nausea or vomiting

Critically, this does not affect the glucagon response to hypoglycemia as this effect is also glucose-dependent

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Overall, GLP-1, GLP-1/GIP, GLP-1/GCGR, and GLP-1/GIP/GCGR agonists are poised to become cornerstones of obesity treatment in adolescents