Animal studies showed beneficial effects without notable side effects
Research also shows there is no difference in the effectiveness of oral, sublingual and intramuscular supplements in raising blood vitamin B12 levels
Vitamin B , Folate, and the Methionine Remethylation Cycle-Biochemistry, Pathways, and Regulation
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However, the use of these compounds has been restricted by regulations due to concerns about their toxicity and carcinogenic effects