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In addition, GLP-1 delays gastric emptying, promotes satiety via central nervous system pathways, and protects pancreatic cells from apoptosis [3, 4, 8, 9]

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MT-II activates multiple melanocortin receptor subtypes particularly MC1R, MC3R, MC4R, and MC5R which gives it a research profile that extends well beyond just tanning

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According to NICE guideline NG28 on type 2 diabetes management and the specific NICE Technology Appraisal for tirzepatide, GLP-1 receptor agonists like Mounjaro may be considered as part of a comprehensive treatment strategy when glycaemic targets are not achieved with other therapies or when weight loss would provide significant clinical benefit

J Endocrinol 2006