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[PubMed: 30932347] 64

Additionally, a randomized, double-blind, placebo-controlled trial in 162 elderly people (70 years) with mild vitamin B 12 deficiency found that vitamin B 12 supplementation for 24 weeks, alone or in combination with folic acid, did not improve memory performance (117)

Megalin is expressed along the apical aspect of proximal tubules, where it is responsible for hepatocyte-derived AGT reabsorption and its homeostasis in kidney

Semaglutide, the active ingredient in Wegovy, reaches peak blood levels 13 days after injection and maintains therapeutic activity for approximately 7 days

Most studies achieve sustainable results from 3 months onwards

doi: 10.3389/fmed.2026.1698091 Received 03 September 2025 Revised 16 March 2026 Accepted 19 March 2026 Published 20 April 2026 Volume 13 - 2026 Edited by Liliana Gabriela Popa, Carol Davila University of Medicine and Pharmacy, Romania Reviewed by Manoj B