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High purity is essential to ensure that the observed biological effects are attributable to the target peptide and not a contaminant

Avoid or reduce the intake of caffeine, soft drinks and alcohol

Moderate deficit works best: 300-500 calorie deficit below maintenance

Caroline Apovian, the co-director of the Center for Weight Management and Wellness at Brigham and Women's Hospital, agrees: "The studies show over and over and over again," Apovian says, that if you stop taking the medications, "you will regain the weight back." Noom isn't the only startup to market GLP-1s as temporary treatments that offer long-term effects

Peptide therapy works by supporting your body's natural functions, so the benefits are typically present as long as you continue the treatment

International Federation for the Surgery of Obesity and Metabolic Disorders