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The freezing and thawing process can denature them, rendering them ineffective

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The testicular blood vessels were congested (Bv), and the interstitial tissue appeared degenerated with loss of a large number of Leydig cells (I)

Extensive research has identified a wide range of exosomal components, including over 41,860 proteins, 7,540 RNAs, and 1,116 lipids, underscoring the complexity and heterogeneity of exosomal cargo [50]