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Gastrointestinal effects of GLP-1 receptor agonists: mechanisms, management, and future directions

For patients with type 2 diabetes or obesity who are interested in GLP-1 therapies, discuss the currently licensed options with your GP, practice nurse, or diabetes specialist nurse

October 22, 2025

A wider medication catalog allows for more personalizationwhat works for one person may not work for another

56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity

Retatrutide is investigated as a triple receptor agonist , interacting with GLP-1 receptors, GIP receptors, and glucagon receptors