Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
Anastrozole is an aromatase inhibitor licensed only for hormone receptor-positive breast cancer in postmenopausal women The medication works by blocking oestrogen production, which may actually worsen sexual function when oestrogen levels drop too low in men NICE guidance does not recommend aromatase inhibitors as a treatment option for erectile dysfunction Off-label use in men carries risks including reduced bone density, unfavourable lipid profiles, and potential worsening of sexual function Evidence-based ED treatments include PDE5 inhibitors like sildenafil, lifestyle modifications, and specialist assessment when hormonal imbalance is suspected Table of Contents What Is Anastrozole and How Does It Work
The diagram below, adapted from the Society of Clinical Research Associates, shows the general timing of HF and clinical studies for combination products
Archived from the original on June 5, 2025
"Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction"
Approved medications can be widely distributed and prescribed by healthcare providers, ensuring that patients have access to effective treatments