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However, research on its safety and efficacy is limited, and it is not currently an approved drug

[DOI] [PMC free article] [PubMed] [Google Scholar] Naqvi S, Zhu C, Farre G, et al

Under normal conditions, HIFs are hydroxylated by the hydroxylase family in an oxygen-dependent manner, which leads to a substantial reduction in the transcriptional activity of HIFs, whereas under hypoxic conditions, the hydroxylate activity is inhibited, and HIFs accumulate in the cytoplasm

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The dual role of sirtuins in cancer: biological functions and implications