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Patients who plateau at a lower dose often experience renewed weight loss after stepping up, because higher circulating levels achieve fuller receptor occupancy in hypothalamic feeding centers

Vukojevic J, et al

The findings shared at #AADInnovation2026 reinforce the promise of this approach and the importance of continuing to advance treatment options

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Subgroup analysis according to IBS subtypes (e.g., IBS-C, IBS-D, IBS-M, and IBS-U) would have offered significant insight on how the intervention differed in its effects on these various patient groups

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