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Certain foods can relax the lower oesophageal sphincter or increase stomach acid production, making reflux worse

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These outcomes align with the results of human trials

The drugs are also regulated differently by the FDA

Various tests of performance, multiple sleep latency, self-report, and nocturnal polysomnography have shown that DSIP exhibits this effect, also through its ability to improve REM sleep and regulate circadian and ultradian rhythms