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60 Long-term, high-dose beta carotene supplementation (2030 mg/day) increases lung cancer mortality by approximately 20% in people who smoke and individuals with prior asbestos exposure, while its photoprotective benefits only become reliable after 6 to 12 weeks at 12 mg/day

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In parallel, mitochondrial fragmentation and stress signaling may alter the plasma membrane lipid microenvironment and reduce the efficiency of membrane protein insertion, thereby compromising OCTN2 anchoring and stability within membrane microdomains [114]

Animal models do not always translate into humans

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