5 Discussion: perspective and open questions While the identification of RAiNs (Sebastian et al., 2012) and VAPB (Janikiewicz et al., 2018), which likely compromise the biophysical environment required for LLPS and biomolecular condensate nucleation in -cells (Huang et al., 2025) or only delay further decay is essential for de-risking clinical translation and defining the therapeutic window for these agents in late-stage pathologies
Chronic inflammation Inflammation and metabolic stress can disrupt gut-hormone communication
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However, this approach can also lead to unpredictable side effect patterns and inconsistent medication efficacy
PaoliAMancinLBiancoAThomasEMotaJFPicciniF.Ketogenic diet and microbiota: Friends or enemies
