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BNIP3 contains a C-terminal region and an N-terminal region [46]

At 13 to 24 months following prescription, participants experienced a 3.8 per cent drop from baseline weight, with those without diabetes seeing even greater reductions of 5.1 per cent

Yanagi, M., Purcell, R

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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment