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Recent gait and imaging analyses further support that morphological features such as tibial plateau slope, femoral condyle shape, and joint congruency significantly affect joint biomechanics, contributing to early onset OA in at-risk individuals (Zhang K

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intra-articular PTP administration upregulates GPX4 and confers antiferroptotic and anti-inflammatory effects on chondrocytes, thereby protecting joint cartilage (174)

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