When considering subjects treated with ALCAR 3 g/day and their propensity score matched not treated subjects, 46% in both groups died within 24 months after baseline (OR 1.00, 95% CI 0.442.29)
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7 How GLP-1 drugs may reshape addiction pathways GLP-1 RAs interact with the mammalian mesolimbic reward system and have been proposed to modulate dopaminergic signaling in circuits involving the ventral tegmental area, nucleus accumbens, and other reward-related regions, thereby reducing the reinforcing value of food and some substances in preclinical models
Research Square Preprint2020 Dec
Min T, Prior SL, Churm R, Dunseath G, Barry JD, Stephens JW