5.1 Synchronized delivery strategy Synchronized delivery of metal ions and sensitizing drugs via NDDS is an effective strategy for inducing both ferroptosis and cuproptosis
Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function
Optimize detoxification, immune function, and longevity
intermittent treatment with senolytics have conclusively reduced senescent cell burden in peripheral tissues (fat, lung, kidney, pancreas, cartilage, and muscle), improved pathologies in these tissues, and extended healthspan and lifespan (45, 46, 100-103)
In vitro studies demonstrated that verapamil, when combined with rifapentine, enhanced antimicrobial activity against M.tb in macrophages [85]
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