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[2] Systemically, angiogenic activity is a double-edged property in principle helpful for perfusing regenerating tissue, but something that any candidate with pro-angiogenic signaling must be evaluated against carefully in other contexts, including any setting where promoting blood-vessel growth would be undesirable

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doi: 10.1007/BF00609183 8 CantinA

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Both factors make the skin remodeling task harder