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Exploration of GSH-degrading enzyme modulators presents a promising avenue for impeding cancer progression, overcoming tumor resistance to pro-oxidative therapy and preserving tumor sensitivity to chemotherapy (Table III)

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Participants were divided into four groups based on the PA levels as previously described [14, 29], including inactive (with no moderate- or vigorous-intensity PA), insufficiently active (with total MET being 0 to 600 METs-min), moderate active (total METs being 600 to 3000), and highly active (total METs more than 3000)