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The reward system is a distributed network with its key structures including the ventral striatum, the anterior cingulate cortex, the orbitofrontal cortex, the ventral pallidum, and the midbrain dopamine neurons (Haber & Knutson, 2010)

Nevertheless, current GSH-activated prodrugs frequently face challenges in achieving selective activation within heterogeneous tumor microenvironments

However, not all delivery methods are equal in safety

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Monitoring framework: ALT and AST at baseline and at 6-month intervals modest elevation (less than 3 the upper limit of normal) may be chronic and pre-existing

BPC-157 is being studied in preclinical models for its potential role in angiogenic activity, cellular migration, and tissue-response pathways