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Fat loss, particularly visceral fat loss, decreases the secretion of pro-inflammatory cytokines

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Patients with certain MC4R variants may experience less appetite control from semaglutide alone and could benefit from dual-compound protocols like GLP-Squared Injection, which combines semaglutide with tirzepatide to address multiple hunger pathways simultaneously

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In addition, labile iron pools can catalyze lipid radical propagation through Fenton-type reactions, further amplifying membrane lipid peroxidation [71, 72]