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JP Richie Jr, S Nichenametla, W Neidig, et al

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Furthermore, identifying specific subgroups of patients who are more vulnerable to the detrimental effects of depression on CHD could help tailor interventions and improve patient outcomes

This is supported by studies showing that ascorbate release occurs before corticosteroid release in the adrenal gland after systemic administration of ACTH to hypophysectomized rats (105), a finding that suggests ascorbate must first be released by the adrenal gland for steroid synthesis (or release) to begin when there is stress

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